Facile Synthesis of Azetidine Nitrones and Diastereoselective Conversion into Densely Substituted Azetidines
نویسندگان
چکیده
منابع مشابه
A facile synthesis of substituted benzyl selenocyanates.
Benzyl selenocyanates can be made from the corresponding benzylic bromides or chlorides in 30-60 minutes using acetonitrile as a solvent. The products may be obtained pure in satisfactory yields without recourse to chromatography.
متن کاملSynthesis of Substituted Oxo-Azepines by Regio- and Diastereoselective Hydroxylation.
Substituted seven-membered N-heterocycles are prevalent bioactive epitopes and useful synthons for preparing enzyme inhibitors or molecular recognition systems. To fully exploit the chemical properties of this flexible N-heterocycle scaffold, efficient methods for its diverse functionalization are required. Here we utilize the late-stage oxidation of tetrahydroazepines as an approach to access ...
متن کاملDiastereoselective synthesis of substituted diaziridines from simple ketones and aldehydes.
Diastereopure substituted diaziridines from simple ketones, aldehydes and amines are here reported. These important chemical scaffolds are obtained in the presence of a weak inorganic base and hydroxylamine O-sulfonic acid (HOSA). This method introduces three stereocenters in one step to provide a wide variety of substituted diaziridines with high yields and diastereoselectivities.
متن کاملsingle-step synthesis of multi-component spirobarbiturates using ionic liquids and synthesis of substituted pyridine filled with catalysts supported on solid substrate
in this thesis, a better reaction conditions for the synthesis of spirobarbiturates catalyzed by task-specific ionic liquid (2-hydroxy-n-(2-hydroxyethyl)-n,n-dimethylethanaminium formate), calcium hypochlorite ca(ocl)2 or n-bromosuccinimide (nbs) in the presence of water at room temperature by ultrasonic technique is provided. the design and synthesis of spirocycles is a challenging task becaus...
15 صفحه اولAntimicrobial potential of various substituted azetidine derivatives
Many serious and life threatening diseases such as tuberculosis are caused by bacteria or fungi infections. Organ transplantation or surgery caused microbial infections are common problem.1,2 Natural, synthetic and semi synthetic antimicrobial drugs have been used against the life threatening infectious diseases.3 Deaths from bacterial and fungal infection have dropped currently, but still thos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2017
ISSN: 1433-7851,1521-3773
DOI: 10.1002/anie.201705681